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Michael P. Whyte, M.D. Professor of Medicine, Pediatrics, and Genetics,
Dr. Whyte earned his M.D. degree at Downstate College of Medicine, State University of New York, Brooklyn, New York and did his internship and residency training in Internal Medicine at Bellevue Hospital in New York City before spending two years as a Clinical Associate at the National Institutes of Health, Bethesda, Maryland. After his fellowship in Endocrinology, he joined the medical faculty of Washington University School of Medicine, St. Louis. He is a medical staff member staff of Barnes-Jewish Hospital, St. Louis Children's Hospital, and Shriners Hospital for Children in St. Louis. He is also the Medical-Scientific Director of the Center for Metabolic Bone Disease and Molecular Research at Shriners Hospital. Dr. Whyte's specialty areas include inherited skeletal disorders and adult and pediatric metabolic bone diseases. Of note, he has authored or coauthored more than 250 scientific papers or book chapters on pediatric and adult metabolic bone diseases. Research Interests Dr. Whyte's research interests include the cause and treatment of especially heritable skeletal disorders in children and adults. Included are genetic forms of rickets such as hypophosphatasia and X-linked hypophosphatemia, brittle bone diseases like osteogenesis imperfecta, and conditions that cause dense bones such as osteopetrosis. Collaborative laboratory investigations include mapping of specific diseases on human chromosomes and then searches for mutated genes. Working with Dr. Mumm, Dr. Whyte couples their molecular findings to the clinical observations to better understand how these conditions develop. His research center at Shriners Hospital serves as a national resource for diagnosis, treatment, and investigation of disorders of bone and mineral metabolism and skeletal dysplasias in children. Selected Publications Whyte MP, Reinus WR, Podgornik MN, and Mills, BG. Familial Expansile Osteolysis (Excessive RANK Effect) in A 5-Generation American Kindred Medicine (Baltimore) 2002; 81: 101-121. Whyte, MP, Obrecht , SE, Finnegan, PM, Jones, JL, Podgornik, MN, McAlister, WH, and Mumm S: Osteoprotegerin Deficiency and Juvenile Paget's Disease New England Journal of Medicine, 2002; 347: 174-184. Whyte MP, Kurtzburg J, McAlister WH, Podgornik MN, Mumm S, Coburn SP, Ryan LM, Miller CR, Gottesman GS, and Martin PL. Marrow Cell Transplantation For Infantile Hypophosphatasia. Journal of Bone and Mineral Research 2003; 18: 624-636. Whyte MP, Wenkert D, Clements KL, McAlister WH, and Mumm S. Bisphosphonate-Induced Osteopetrosis. New England Journal of Medicine 2003; 349: 455-461. Watts GDJ, Wymer J, Mehta SG, Mumm S, Pestronk A, Whyte MP, and Kimonis VE.: Inclusion Body Myopathy - Paget Bone Disease - Frontotemporal Dementia Syndrome Caused by Mutated Valosin Containing Protein. Nature Genetics 2004; 36:377-81. Whyte MP. Approach to The Patient With Metabolic Bone Disease in "Vitamin D" (2nd Ed,) Feldman D, Glorieux F, Pike W (editors). Academic Press, San Diego 2005, pp 913-929. Whyte MP, Essmyer K, Gannon FH, and Reinus WR.: Skeletal Fluorosis and Instant Tea. American Journal of Medicine 2005; 118: 78-82. Wyckoff MH, El-Turk C, Laptook A, Timmons C, Gannon FH, Zhang X, Mumm S, and Whyte MP. Neonatal Lethal Osteochondrodysplasia with Low Serum Levels Of Alkaline Phosphatase And Osteocalcin. Journal of Clinical Endocrinology and Metabolism 2005; 90: 1233-1240. Whyte MP. Misinterpretation Of Osteodensitometry with High Bone Density (BMD Z ≥ + 2.5 Is Not "Normal"). Journal of Clinical Densitometry 2005; 8: 1-6. Rickels MR, Zhang X, Mumm S, and Whyte MP. Oropharyngeal Skeletal Disease Accompanying High Bone Mass and Novel LRP5 Mutation. Journal of Bone and Mineral Research 2005; 20:878-885.
Division of Bone & Mineral Diseases
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