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Deborah Novack, MD, PhD Assistant Professor of Medicine
Dr. Novack completed the MD/PhD program at Washington University, St. Louis, MO. She is board certified in Anatomic Pathology and was trained at Barnes-Jewish Hospital at Washington University. Dr. Novack was a postdoctoral fellow in the laboratory of Steven Teitelbaum.1993. She has received several awards which include the 2001 ASBMR Young Investigator Award and the 2004 Harold Frost Young investigator Award. Research Interests Dr. Novack's laboratory focuses on the role of the NF-κB transcription factor family in osteoclast differentiation and function. Osteoclasts are bone marrow-derived cells whose activity is responsible for loss of bone mass, particularly in pathologic states such as postmenopausal osteoporosis, inflammatory arthritis, and metastasis of tumors to bone. She is using a variety of approaches, including the analysis of gene-deleted (knockout) and transgenic mice, the induction of disease states in mice, and in vitro culture of osteoclasts. Novack Lab 
Selected Publications Cenci S, Weitemann MN, Roggia C, Namba N, Novack D, Woodring J, and Pacifici R: Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α. J Clin Invest 2000; 106: 1203-1204. Novack DV, Feng X, Faccio R, Ory DS, Aya K, Boyer MI, McHugh KP, Ross FP, and Teitelbaum SL: A Glanzmann's mutation in β3 integrin specifically impairs osteoclast function. J Clin Invest 2001: 107: 1137-1144. Weng S, Zemany L, Standley KN, Novack DV, La Regina M, Bernal-Mizrachi C, Coleman T, Semenkovich CF. β3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proc Natl Acad Sci U S A. 2003; 100:6730-5. Faccio R, Novack DV, Zallone A, Ross FP, Teitelbaum SL. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin. J Cell Biol. 2003; 162: 499-509. Novack DV, Yin L, Hagen-Stapleton A, Schreiber RD, Goeddel DV, Ross FP, Teitelbaum SL. The IκB function of NF-κB2 p100 controls stimulated osteoclastogenesis. J Exp. Med. 2003, 198; 771-781. Choi ET, Khan MF, Leidenfrost BA, Collins ET, Boc KP, Villa BR, Novack DV, Parks WC, and Abendschein DR. β3 integrin mediates smooth muscle cell accumulation in neointima arfter carotid ligation in mice. Circulation 2004; 109: 1564-9. Kitaura H, Sands MS, Aya K, Zhou P, Hirayama T, Uthgenannt B, Wei S, Takeshita S, Novack DV, Silva MJ, Abu-Amer Y, Ross FP, Teitelbaum SL. Marrow stromal cells and osteoclast precursors differentially contribute to TNF-α-induced osteoclastogenesis in vivo. J Immunol. 2004;173(8):4838-46. Aya K, Alhawagri M, Hagen-Stapleton A., Kitaura H, Kanagawa O, and Novack DV. NIK controls lymphocyte and osteoclast activities in inflammatory arthritis. J. Clin. Invest. 2005, in press. Zhao, H, Kitaura, H, Sands, MS, Ross,FP, Teitelbaum,SL, Novack,DV, Critical role of β3 integrin in experimental post-menopausal osteoporosis. J.Bone and Mineral Research, 2005; in press.
Division of Bone & Mineral Diseases
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